Bilateral rhabdoid meningioma mimicking glioma: an unusual occurrence

000253 10.3205/000253 urn:nbn:de:0183-0002533 Case Report Bilateral rhabdoid meningioma mimicking glioma: an unusual occurrence Beidseitiges Gliom-imitierendes rhabdoides Meningeom: ein seltener Fall Dalal Dalal Varsha V

National Institute of Pathology, Indian Council of Medical Research (ICMR), New Delhi, India

author Siraj Siraj Fouzia F

National Institute of Pathology, Indian Council of Medical Research (ICMR), Sriramachari Bhawan, Safdarjung Hospital Campus, New Delhi – 110029, IndiaNational Institute of Pathology, Indian Council of Medical Research (ICMR), New Delhi, India

fouziasiraj2009@gmail.com author Kaur Kaur Manveen M

National Institute of Pathology, Indian Council of Medical Research (ICMR), New Delhi, India

author Shankar Shankar K.B. KB

Department of Neurosurgery, Safdarjung Hospital, New Delhi, India

author Singh Singh Avninder A

National Institute of Pathology, Indian Council of Medical Research (ICMR), New Delhi, India

author German Medical Science GMS Publishing House

Düsseldorf

610 bilateral meningioma rhabdoid bilateral Meningeom rhabdoid Neurology 20161202 20170713 20170814 engl This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). 1612-3174 15 GMS German Medical Science GMS Ger Med Sci 12 Das rhabdoide Meningeom ist eine seltene Meningeom-Variante, die erstmals im Jahr 2000 in die WHO-Klassifikation von Tumoren des zentralen Nervensystems aufgenommen wurde. Aufgrund ihrer Aggressivität und hohen Proliferation wurde sie als Grad III-Neoplasie klassifiziert. Wir berichten über einen 50-jährigen Mann mit Kopfschmerzen, Schwäche der Extremitäten und verändertem Empfindungsvermögen. Das CT zeigte heterodense, sich vergrößernde Läsionen sowohl in der rechten als auch in der linken Parietalregion, die auf ein hochgradiges Gliom hinwiesen. Histopathologische und immunhistochemische Untersuchungen ließen einen Tumor mit Eigenschaften eines rhabdoiden Meningeoms erkennen. In der ausgewerteten Fachliteratur konnte kein Fall eines beidseitig auftretenden Tumors gefunden werden. Rhabdoid meningioma is an infrequent variant of meningioma, introduced for the first time in the 2000 World Health Organization’s classification of tumors of the nervous system. Owing to its aggressive clinical course and high proliferative index, it has been classified as a grade III neoplasm. We describe a fifty-year-old male with headache, weakness of limbs, and altered sensorium. CT showed hetero-dense enhancing mass lesions in both right and left parietal areas raising suspicion of high grade glioma. Histopathologic and immunohistochemical examination revealed a tumor with features of rhabdoid meningioma. A review of literature did not reveal any bilateral occurrence of this tumor. IntroductionMeningiomas are tumors of meningothelial origin having a wide range of histological appearances. They are most commonly benign and slow growing in nature. Some subtypes however are recognized to display aggressive behavior including atypical, clear cell, chordoid meningiomas (WHO grade II) and papillary and anaplastic variants belonging to WHO grade III , . Recently, rhabdoid meningiomas have been added to the grade III subtype. These anaplastic meningiomas represent 1–2% of all meningiomas. They are associated with rapid growth, brain invasion and frequent recurrences , . Case descriptionA 50-year-old male presented with headache since the past two months. He also complained of weakness in both upper and lower limbs and altered sensorium for the past fifteen days. On physical examination, the patient was conscious with a GCS of E4M6V4. The power was reduced on the left side (3/5), but maintained on the right side (5/5). Computed tomography (CT) revealed well defined hetero-dense masses measuring 5x4 cm and 2x2 cm in the right and the left parietal region respectively with surrounding edema and mass effect (Figure 1 ). A diagnosis of glioblastoma multiforme was suggested. Total excision of both the masses was done and they were sent for examination. Histopathology of both lesions showed a tumor with cells arranged diffusely in sheets as well as scattered singly. The cells had abundant amounts of eosinophilic cytoplasm, eccentrically placed nuclei, and prominent nucleoli. Areas of high mitotic activity and necrosis were also noted (Figure 2 ). The possibilities considered were glioblastoma multiforme, metastases, melanoma, plasmacytoma, and rhabdoid meningioma. On IHC (immunohistochemistry), the tumor cells were negative for GFAP, CK, HMB-45 and showed diffuse positivity for D2-40 and vimentin. Focal positivity for EMA was also observed. The high mitotic activity was highlighted by Ki67 positivity demonstrating a mean labeling index of 15% (Figure 3 ). Absence of pigment and HMB-45</PlainText></TextGroup> reactivity ruled out a melanocytic lesion. Absence of mott cells and CD 138 reactivity ruled out plasmacytoma. Absence of any other primary lesion on imaging and CK negativity eliminated metastatic carcinoma. GFAP negativity excluded the possibility of glioma. Finally, EMA, <TextGroup><PlainText>D2-40</PlainText></TextGroup>, and vimentin positivity confirmed the meningeal nature of the tumor cells. Thus, a final diagnosis of bilateral rhabdoid meningioma was rendered. Often, the presence of classical areas of meningothelial appearance in the tumor help in reaching the diagnosis <TextLink reference="1"></TextLink>. However, these were absent in the present case. Postoperatively, there was improvement in the neurological deficit and subsequently, the patient was put on radiotherapy. He received 30 cycles of radiotherapy with a radiation dose of 60 Gy. Till one year follow-up, the patient is asymptomatic and doing well. </Pgraph></TextBlock> <TextBlock linked="yes" name="Discussion"> <MainHeadline>Discussion</MainHeadline><Pgraph>Meningiomas are neoplasms thought to derive from arachnoidal cap cells in the meningeal coverings of the spinal cord and brain. Meningiomas are generally benign, slow growing tumors which produce neurological symptoms and signs due to their compression of adjacent structures <TextLink reference="5"></TextLink>. The incidence of meningiomas in India ranges from 9–15% of all intracranial neoplasms according to a study done by Dr. A. Vincent Thamburaj <TextLink reference="6"></TextLink>. Rhabdoid meningiomas were described for the first time in 1998 as an unusual variant with increased proliferative activity. Later, in 2000, these tumors were included in the revised WHO classification of CNS tumors as an aggressive meningioma corresponding to WHO grade III <TextLink reference="1"></TextLink>, <TextLink reference="3"></TextLink>. </Pgraph><Pgraph>The most commonly affected age groups are the 5<Superscript>th</Superscript> to 7<Superscript>th</Superscript> decades with a marked female preponderance (11:4). The more aggressive subtypes usually present in younger age groups <TextLink reference="1"></TextLink>. Our patient, however, was an elderly male. Presenting symptoms include seizures, hemiparesis, and gait disturbance depending on the site of the tumor <TextLink reference="1"></TextLink>, <TextLink reference="5"></TextLink>. </Pgraph><Pgraph>The term rhabdoid in this tumor refers to the classical morphology of the tumor cell which bears close resemblance to a rhabdomyoblast without true skeletal muscle differentiation <TextLink reference="7"></TextLink>. Numerous tumors may exhibit such phenotype viz. glioblastoma multiforme, metastases, melanoma, plasmacytoma. They were therefore considered as differentials in the present case and were subsequently ruled out on the basis of immunohisto<TextGroup><PlainText>chemistry.</PlainText></TextGroup> Apart from this typical morphology, rhabdoid meningioma also exhibits a high level of atypia, mitoses and necrosis. Ki67 (MIB-1) is a valuable guide to malignancy in meningioma. The mean labeling index for such tumors is 14.7% ± 9.8% <TextLink reference="2"></TextLink>, which was 15% in our case. </Pgraph><Pgraph>Multiplicity in meningiomas attracts a lot of interest because of its relative rarity, unclear aetiology, and the problems related to proper management strategy. Majority of multiple meningiomas (80–90%) are benign and classified as WHO grade I. Anaplastic or malignant <TextGroup><PlainText>meningiomas</PlainText></TextGroup> (WHO grade III) are the rarest (1–3%) <TextLink reference="8"></TextLink>, <TextLink reference="9"></TextLink>. Tomita et al. described multiple meningiomas consisting of fibrous meningioma and anaplastic meningioma <TextLink reference="10"></TextLink>. The occurrence of multiple rhabdoid meningioma has not been reported in literature till date. </Pgraph><Pgraph>Rhabdoid meningiomas are associated with rapid growth, brain invasion, and frequent recurrences <TextLink reference="1"></TextLink>. They also show a propensity to metastasize extracranially (7–43%); lung being the most common site, followed by bone, liver, lymph node, and kidneys. Median overall survival (OS) has been reported to be 1.5 years with a 5-year survival ranging from 47% to 61% <TextLink reference="11"></TextLink>. Surgery is the sole modality of treatment followed by whole brain radiation therapy (WBRT), usually in doses ranging from 50 to 60 Gy of radiation via conventional fractionation and delivery techniques. Some studies also recommend the use of gamma knife stereotactic radiosurgery in such aggressive cases to prevent recurrence <TextLink reference="12"></TextLink>. Good prognostic factors include aggressive gross total resection, de novo status, and location along the convexity/parasagittal intracranial areas <TextLink reference="11"></TextLink>. </Pgraph></TextBlock> <TextBlock linked="yes" name="Notes"> <MainHeadline>Notes</MainHeadline><SubHeadline>Competing interests</SubHeadline><Pgraph>The authors declare that they have no competing interests.</Pgraph></TextBlock> <References linked="yes"> <Reference refNo="1"> <RefAuthor>Perry A</RefAuthor> <RefAuthor>Louis DN</RefAuthor> <RefAuthor>Scheithauer BW</RefAuthor> <RefAuthor></RefAuthor> <RefTitle>Meningeal tumours</RefTitle> <RefYear>2007</RefYear> <RefBookTitle>WHO classification of tumours of the central nervous system</RefBookTitle> <RefPage>163-72</RefPage> <RefTotal>Perry A, Louis DN, Scheithauer BW, et al. Meningeal tumours. In: Louis DN, Ohgaki H, Weistler OD, Cavenee WK, eds. WHO classification of tumours of the central nervous system. 4th ed. Lyon: IARC; 2007. p. 163-72.</RefTotal> </Reference> <Reference refNo="2"> <RefAuthor>Kar A</RefAuthor> <RefAuthor>Rath G</RefAuthor> <RefAuthor>Mohanty L</RefAuthor> <RefAuthor>Behera P</RefAuthor> <RefAuthor>Mohapatro S</RefAuthor> <RefAuthor></RefAuthor> <RefTitle>Rhabdoid Meningioma – an uncommon and aggressive variant</RefTitle> <RefYear>2013</RefYear> <RefJournal>J Cancer Sci Ther</RefJournal> <RefPage>343-5</RefPage> <RefTotal>Kar A, Rath G, Mohanty L, Behera P, Mohapatro S, et al. Rhabdoid Meningioma – an uncommon and aggressive variant. J Cancer Sci Ther. 2013;5:343-5. DOI:10.4172/1948-5956.1000225</RefTotal> <RefLink>http://dx.doi.org/10.4172/1948-5956.1000225</RefLink> </Reference> <Reference refNo="3"> <RefAuthor>Mardi K</RefAuthor> <RefAuthor>Thakur RC</RefAuthor> <RefAuthor>Biswas B</RefAuthor> <RefTitle>Rhabdoid meningioma lacking malignant features: Report of a rare case with review of literature</RefTitle> <RefYear>2015</RefYear> <RefJournal>Asian J Neurosurg</RefJournal> <RefPage>172-4</RefPage> <RefTotal>Mardi K, Thakur RC, Biswas B. Rhabdoid meningioma lacking malignant features: Report of a rare case with review of literature. Asian J Neurosurg. 2015 Apr-Jun;10(2):172-4. DOI: 10.4103/1793-5482.153499</RefTotal> <RefLink>http://dx.doi.org/10.4103/1793-5482.153499</RefLink> </Reference> <Reference refNo="4"> <RefAuthor>Reddy ChK</RefAuthor> <RefAuthor>Rao AD</RefAuthor> <RefAuthor>Ballal CK</RefAuthor> <RefAuthor>Chakraborti S</RefAuthor> <RefTitle>Rhabdoid meningioma: report of two cases</RefTitle> <RefYear>2015</RefYear> <RefJournal>J Clin Diagn Res</RefJournal> <RefPage>PD05-6</RefPage> <RefTotal>Reddy ChK, Rao AD, Ballal CK, Chakraborti S. Rhabdoid meningioma: report of two cases. J Clin Diagn Res. 2015 Feb;9(2):PD05-6. DOI: 10.7860/JCDR/2015/11163.5571</RefTotal> <RefLink>http://dx.doi.org/10.7860/JCDR/2015/11163.5571</RefLink> </Reference> <Reference refNo="5"> <RefAuthor>Kaur M</RefAuthor> <RefAuthor>Dalal V</RefAuthor> <RefAuthor>Sharma KC</RefAuthor> <RefAuthor>Singh A</RefAuthor> <RefTitle>Lymphoplasmacyte-rich meningioma – a rare morphological variant of meningioma</RefTitle> <RefYear>2016</RefYear> <RefJournal>Br J Med Pract</RefJournal> <RefPage>a905</RefPage> <RefTotal>Kaur M, Dalal V, Sharma KC, Singh A. Lymphoplasmacyte-rich meningioma – a rare morphological variant of meningioma. Br J Med Pract. 2016;9(1):a905</RefTotal> </Reference> <Reference refNo="6"> <RefAuthor>Srilaxmi S</RefAuthor> <RefTitle>Meningiomas: a clinicopathological study</RefTitle> <RefYear>2015</RefYear> <RefJournal>Int J Med Res Health Sci</RefJournal> <RefPage>827-31</RefPage> <RefTotal>Srilaxmi S. Meningiomas: a clinicopathological study. Int J Med Res Health Sci. 2015;4(4):827-31. DOI: 10.5958/2319-5886.2015.00164.2</RefTotal> <RefLink>http://dx.doi.org/10.5958/2319-5886.2015.00164.2</RefLink> </Reference> <Reference refNo="7"> <RefAuthor>Jansen JC</RefAuthor> <RefAuthor>Turner J</RefAuthor> <RefAuthor>Sheehy J</RefAuthor> <RefAuthor>Fagan PA</RefAuthor> <RefTitle>Recurrent rhabdoid meningioma: case report</RefTitle> <RefYear>2003</RefYear> <RefJournal>Skull Base</RefJournal> <RefPage>51-4</RefPage> <RefTotal>Jansen JC, Turner J, Sheehy J, Fagan PA. Recurrent rhabdoid meningioma: case report. Skull Base. 2003 Feb;13(1):51-4. DOI: 10.1055/s-2003-820557</RefTotal> <RefLink>http://dx.doi.org/10.1055/s-2003-820557</RefLink> </Reference> <Reference refNo="8"> <RefAuthor>Koech F</RefAuthor> <RefAuthor>Orege J</RefAuthor> <RefAuthor>Ndiangui F</RefAuthor> <RefAuthor>Macharia B</RefAuthor> <RefAuthor>Mbaruku N</RefAuthor> <RefTitle>Multiple intracranial meningiomas: a review of the literature and a case report</RefTitle> <RefYear>2013</RefYear> <RefJournal>Case Rep Surg</RefJournal> <RefPage>131962</RefPage> <RefTotal>Koech F, Orege J, Ndiangui F, Macharia B, Mbaruku N. Multiple intracranial meningiomas: a review of the literature and a case report. Case Rep Surg. 2013;2013:131962. DOI: 10.1155/2013/131962</RefTotal> <RefLink>http://dx.doi.org/10.1155/2013/131962</RefLink> </Reference> <Reference refNo="9"> <RefAuthor>Wong RH</RefAuthor> <RefAuthor>Wong AK</RefAuthor> <RefAuthor>Vick N</RefAuthor> <RefAuthor>Farhat HI</RefAuthor> <RefTitle>Natural history of multiple meningiomas</RefTitle> <RefYear>2013</RefYear> <RefJournal>Surg Neurol Int</RefJournal> <RefPage>71</RefPage> <RefTotal>Wong RH, Wong AK, Vick N, Farhat HI. Natural history of multiple meningiomas. Surg Neurol Int. 2013;4:71. DOI: 10.4103/2152-7806.112617</RefTotal> <RefLink>http://dx.doi.org/10.4103/2152-7806.112617</RefLink> </Reference> <Reference refNo="10"> <RefAuthor>Tomita T</RefAuthor> <RefAuthor>Kurimoto M</RefAuthor> <RefAuthor>Yamatani K</RefAuthor> <RefAuthor>Nagai S</RefAuthor> <RefAuthor>Kuwayama N</RefAuthor> <RefAuthor>Hirashima Y</RefAuthor> <RefAuthor>Endo S</RefAuthor> <RefTitle>Multiple meningiomas consisting of fibrous meningioma and anaplastic meningioma</RefTitle> <RefYear>2003</RefYear> <RefJournal>J Clin Neurosci</RefJournal> <RefPage>622-4</RefPage> <RefTotal>Tomita T, Kurimoto M, Yamatani K, Nagai S, Kuwayama N, Hirashima Y, Endo S. Multiple meningiomas consisting of fibrous meningioma and anaplastic meningioma. J Clin Neurosci. 2003 Sep;10(5):622-4.</RefTotal> </Reference> <Reference refNo="11"> <RefAuthor>Moliterno J</RefAuthor> <RefAuthor>Cope WP</RefAuthor> <RefAuthor>Vartanian ED</RefAuthor> <RefAuthor>Reiner AS</RefAuthor> <RefAuthor>Kellen R</RefAuthor> <RefAuthor>Ogilvie SQ</RefAuthor> <RefAuthor>Huse JT</RefAuthor> <RefAuthor>Gutin PH</RefAuthor> <RefTitle>Survival in patients treated for anaplastic meningioma</RefTitle> <RefYear>2015</RefYear> <RefJournal>J Neurosurg</RefJournal> <RefPage>23-30</RefPage> <RefTotal>Moliterno J, Cope WP, Vartanian ED, Reiner AS, Kellen R, Ogilvie SQ, Huse JT, Gutin PH. Survival in patients treated for anaplastic meningioma. J Neurosurg. 2015 Jul;123(1):23-30. DOI: 10.3171/2014.10.JNS14502</RefTotal> <RefLink>http://dx.doi.org/10.3171/2014.10.JNS14502</RefLink> </Reference> <Reference refNo="12"> <RefAuthor>Mori Y</RefAuthor> <RefAuthor>Tsugawa T</RefAuthor> <RefAuthor>Hashizume C</RefAuthor> <RefAuthor>Kobayashi T</RefAuthor> <RefAuthor>Shibamoto Y</RefAuthor> <RefTitle>Gamma knife stereotactic radiosurgery for atypical and malignant meningiomas</RefTitle> <RefYear>2013</RefYear> <RefJournal>Acta Neurochir Suppl</RefJournal> <RefPage>85-9</RefPage> <RefTotal>Mori Y, Tsugawa T, Hashizume C, Kobayashi T, Shibamoto Y. Gamma knife stereotactic radiosurgery for atypical and malignant meningiomas. Acta Neurochir Suppl. 2013;116:85-9. DOI: 10.1007/978-3-7091-1376-9_13</RefTotal> <RefLink>http://dx.doi.org/10.1007/978-3-7091-1376-9_13</RefLink> </Reference> </References> <Media> <Tables> <NoOfTables>0</NoOfTables> </Tables> <Figures> <Figure format="png" height="675" width="395"> <MediaNo>1</MediaNo> <MediaID>1</MediaID> <Caption><Pgraph><Mark1>Figure 1: CT image showing hetero-dense lesions in both right and left parietal areas</Mark1></Pgraph></Caption> </Figure> <Figure format="png" height="422" width="810"> <MediaNo>2</MediaNo> <MediaID>2</MediaID> <Caption><Pgraph><Mark1>Figure 2(a): Section showing tumor with large areas of necrosis (H&E 40X); (b): Large polygonal cells with abundant eosinophilic cytoplasm, eccentric nuclei, prominent nucleoli and brisk mitoses (H&E 400X)</Mark1></Pgraph></Caption> </Figure> <Figure format="png" height="331" width="810"> <MediaNo>3</MediaNo> <MediaID>3</MediaID> <Caption><Pgraph><Mark1>Figure 3: Immunohistochemistry showing positivity for (a): EMA, (b): D2-40, (c): Ki67</Mark1></Pgraph></Caption> </Figure> <NoOfPictures>3</NoOfPictures> </Figures> <InlineFigures> <NoOfPictures>0</NoOfPictures> </InlineFigures> <Attachments> <NoOfAttachments>0</NoOfAttachments> </Attachments> </Media> </OrigData> </GmsArticle>