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      <Title language="en">The development of quality of life and hearing ability of adult cochlear implant users in the course of outpatient cochlear implant follow-up therapy</Title>
      <TitleTranslated language="de">Die Entwicklung der Lebensqualit&#228;t und des H&#246;rverm&#246;gens erwachsener Cochlea-Implantat-Tr&#228;ger im Verlauf der ambulanten Cochlea-Implantat-Folgetherapie</TitleTranslated>
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        <PersonNames>
          <Lastname>Metzeld</Lastname>
          <LastnameHeading>Metzeld</LastnameHeading>
          <Firstname>Dennis</Firstname>
          <Initials>D</Initials>
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        <Address>Cochlear Implant Centre Rhein-Main, Gr&#252;ner Weg 9, 61169 Friedberg, Germany<Affiliation>Cochlear Implant Centre Rhein-Main, Friedberg, Germany</Affiliation></Address>
        <Email>dmetzeld&#64;cic-rheinmain.de</Email>
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        <PersonNames>
          <Lastname>Seebens</Lastname>
          <LastnameHeading>Seebens</LastnameHeading>
          <Firstname>Yvonne</Firstname>
          <Initials>Y</Initials>
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        <Address>
          <Affiliation>Cochlear Implant Centre Rhein-Main, Friedberg, Germany</Affiliation>
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        <PersonNames>
          <Lastname>Helbig</Lastname>
          <LastnameHeading>Helbig</LastnameHeading>
          <Firstname>Silke</Firstname>
          <Initials>S</Initials>
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        <Address>
          <Affiliation>Cochlear Implant Centre Rhein-Main, Friedberg, Germany</Affiliation>
          <Affiliation>Goethe University Frankfurt, University Hospital, ENT-Department, Clinic for Otorhinolaryngology, Frankfurt am Main, Germany</Affiliation>
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          <Corporatename>German Medical Science GMS Publishing House</Corporatename>
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        <Address>D&#252;sseldorf</Address>
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      <SubjectheadingDDB>610</SubjectheadingDDB>
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    <DatePublished>20241217</DatePublished></DatePublishedList>
    <Language>engl</Language>
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      <AltText language="en">This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License.</AltText>
      <AltText language="de">Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung).</AltText>
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      <Journal>
        <ISSN>2628-9083</ISSN>
        <Volume>6</Volume>
        <JournalTitle>GMS Zeitschrift f&#252;r Audiologie - Audiological Acoustics</JournalTitle>
        <JournalTitleAbbr>GMS Z Audiol (Audiol Acoust)</JournalTitleAbbr>
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    <ArticleNo>27</ArticleNo>
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    <Abstract language="de" linked="yes"><Pgraph><Mark1>Fragestellung:</Mark1> Die Steigerung der H&#246;rf&#228;higkeit von postlingual ertaubten Patienten mit Cochlea-Implantaten (CI) wird in der Regel mit Hilfe verschiedener audiometrischer Tests gemessen. Zudem wird auch eine Vielzahl unterschiedlicher subjektiver Messverfahren zur h&#246;rbezogenen und allgemeinen Lebensqualit&#228;t der Patienten (QoL) eingesetzt. Nur wenige Studien befassen sich mit der Entwicklung im Verlauf der h&#228;ufig erforderlichen station&#228;ren oder ambulanten H&#246;rrehabilitation. Ziel der vorliegenden Untersuchung war es, die Entwicklung erwachsener CI-versorgter Patienten im Verlauf der ambulanten Folgetherapie zu messen.</Pgraph><Pgraph><Mark1>Methoden:</Mark1> Getestet wurden 58 Patienten im Alter zwischen 14 und 8<TextGroup><PlainText>4 Jahre</PlainText></TextGroup>n. Die Messungen mittels Freiburger und Oldenburger Satztest (OLSA-Test) sowie dem Nijmegen Cochlear Implant Questionnaire (NCIQ) erfolgten jeweils zu Beginn und am Ende einer Rehabilitationsphase der Folgetherapie. </Pgraph><Pgraph><Mark1>Ergebnisse:</Mark1> In allen Subkategorien des NCIQ sowie im Gesamtscore und auch bei den meisten audiologischen Messungen ergeben sich im Laufe einer Rehabilitationsphase signifikante Verbesserungen mit niedrigen bis mittleren Effektst&#228;rken. Dabei verbessern sich insbesondere die Patienten, die zu Anfang der Rehabilitationsphase geringere Werte aufwiesen. Die Verbesserungen sind unabh&#228;ngig von der Dauer der Rehabilitationsphase. Zu Beginn der Rehabilitationsphase ergeben sich signifikante Korrelationen beim OLSA mit den h&#246;rn&#228;heren Subsk<TextGroup><PlainText>a</PlainText></TextGroup>len des NCIQ, jedoch erst am Ende der Rehabilitationsphase mit den Skalen, die die psychosoziale Zufriedenheit der Patienten charakterisieren.</Pgraph><Pgraph><Mark1>Schlussfolgerungen:</Mark1> Insbesondere Patienten mit schlechterer Ausgangslage zu Beginn der Rehabilitationsphase scheinen von der ambulanten Folgetherapie sowohl objektiv messbar als auch bez&#252;glich ihrer subjektiv empfundenen Lebensqualit&#228;t zu profitieren. Die Zugewinne in beiden Bereichen entwickeln sich offenbar nicht in derselben Geschwindigkeit: M&#246;glicherweise muss sich die verbesserte H&#246;rf&#228;higkeit erst im Alltag bew&#228;hren, um langfristig zu einer h&#246;heren subjektiv empfundenen Lebensqualit&#228;t zu f&#252;hren.</Pgraph></Abstract>
    <Abstract language="en" linked="yes"><Pgraph><Mark1>Research question:</Mark1> The increase in hearing ability of postlingually deafened patients with cochlear implants (CI) is usually measured using various audiometric tests. In addition, a variety of different subjective measures of patients&#8217; hearing-related and general quality of life (QoL) are also used. Only a few studies deal with the development in the course of the frequently required inpatient or outpatient hearing r<TextGroup><PlainText>eh</PlainText></TextGroup>ab<TextGroup><PlainText>ilitatio</PlainText></TextGroup>n. The aim of the present study was to measure the development of adult CI patients in the course of outpatient follow-up therapy.</Pgraph><Pgraph><Mark1>Methods:</Mark1> 58 patients between the ages of 14 and 84 were tested. The measurements using the Freiburg and Oldenburg Sentence (OLSA) Tests and the Nijmegen Cochlear Implant Questionnaire (NCIQ) were taken at the beginning and end of each rehabilitation phase of follow-up therapy. </Pgraph><Pgraph><Mark1>Results:</Mark1> In all subcategories of the NCIQ and in the overall score, as well as in most audiological measurements, there are significant improvements with small to medium effect sizes over the course of a rehabilitation phase. Patients who had lower scores at the beginning of the rehabilitation phase improved in particular. The improvements are independent of the duration of the rehabilitation phase. At the beginning of the rehabilitation phase, there are significant correlations in the OLSA with the subscales of the NCIQ that are closer to hearing, but only at the end of the rehabilitation phase with the scales that characterize the psychosocial satisfaction of the patients.</Pgraph><Pgraph><Mark1>Conclusions:</Mark1> In particular, patients with a poorer starting position at the beginning of the rehabilitation phase appear to benefit from outp<TextGroup><PlainText>a</PlainText></TextGroup>tient follow-up therapy both in terms of objective measurements and in terms of their subjectively perceived quality of life.  The gains in both areas do not seem to develop at the same speed: it is possible that the improved hearing ability must first prove itself in everyday life in order to lead to a higher subjectively perceived quality of life in the long term.</Pgraph></Abstract>
    <TextBlock linked="yes" name="Research question">
      <MainHeadline>Research question</MainHeadline><Pgraph>Hearing tests such as the Oldenburg Sentence Test (OLSA) or the Freiburg mono- and multisyllabic speech test are usually used to check improved hearing ability after CI fitting. However, despite good results in these tests, patients often perceive limitations in everyday communication and in their hearing-related psychosocial situation. The correlations between the audiological measurements on the one hand and the results of the QoL questionnaires on the other are rather low in most studies <TextLink reference="1"></TextLink>, <TextLink reference="2"></TextLink>. Therefore, in parallel to the audiological measurement data, numerous studies also use a variety of different subjective measurement methods for patients&#8217; hearing-related and general quality of life (QoL) <TextLink reference="3"></TextLink>. In the case of hearing-related QoL questionnaires usually show improvements, whereas the results of questionnaire instruments for general QoL are often less clear <TextLink reference="1"></TextLink>. Most studies focus on comparing the results of patients before and after implantation. Only a few studies look at the development over the course of inpatient or outpatient hearing rehabilitation.</Pgraph><Pgraph>Several studies have used various personality variables, cognitive performance and socio-demographic data of patients to try to predict the gain in patients&#8217; quality of life as a result of CI fitting, with little success to date <TextLink reference="2"></TextLink>, <TextLink reference="4"></TextLink>, <TextLink reference="5"></TextLink>.</Pgraph><Pgraph>The aim of the present study was to measure the development of adult CI patients over the course of outpatient follow-up therapy. To this end, audiological measurements and the Nijmegen Cochlear Implant Questionnaire (NCIQ) <TextLink reference="6"></TextLink> in the German translation of Hirschfelder et al. <TextLink reference="5"></TextLink> were compared at the beginning and end of a rehabilitation phase. The NCIQ is also recommended in the S2K Guidelines for the Cochlear Implant treatment <TextLink reference="7"></TextLink>. The questionnaire is directly hearing related, and comprises three functional and three psychosocial subscales. The following questions were to be answered: </Pgraph><Pgraph><OrderedList><ListItem level="1" levelPosition="1" numString="1.">Are there significant improvements in NCIQ and audiometric tests within a rehabilitation phase&#63; </ListItem><ListItem level="1" levelPosition="2" numString="2.">Are the measurements of the variables at T1 and&#47;or T2 related&#63; </ListItem><ListItem level="1" levelPosition="3" numString="3.">Are there definable groups that show particular improvement&#63; </ListItem></OrderedList></Pgraph></TextBlock>
    <TextBlock linked="yes" name="Methods">
      <MainHeadline>Methods</MainHeadline><Pgraph>The sample comprised a total of 58 patients (35 f, 23 m) between the ages of 14 and 84 years (MW&#61;58.61; SD&#61;17.49). Of these, 11 patients were unilaterally deaf, of the 4<TextGroup><PlainText>7 p</PlainText></TextGroup>at<TextGroup><PlainText>ient</PlainText></TextGroup>s with bilateral deafness, 14 patients were fitted with CIs on both sides, 25 wore a hearing aid on the side not fitted with a CI, one wore a BAHA and <TextGroup><PlainText>7 w</PlainText></TextGroup>ere unilaterally unaided. The measurements were taken at the beginning (T1) and end (T2) of the rehabilitation phase. The duration of the rehabilitation phase was quite different (M&#61;6.8 months; SD&#61;5.3 months), since every patient could spread the 30 appointments as time allowed. When those appointments were met and the patient was still in need of rehabilitation, another 1<TextGroup><PlainText>5 a</PlainText></TextGroup>ppointments could be requested from the health insurance company of the patient. These appointment blocks of rehabilitation were called rehabilitation phases. Of the 58 patients, 34 were in their first rehabilitation phase, 24 were in the second or a later phase. The Freiburg mono- and multisyllabic speech test was administered one-sided under free-field conditions at 65 dB SPL with a one meter distance to the loudspeakers. The OLSA was administered under free-field condition: In quiet non-a<TextGroup><PlainText>dapt</PlainText></TextGroup>ive at 65 dB SPL, and in noise the L50 value was determined adaptively. Both the OLSA in quiet as well as in noise were tested in best-aided condition. The Freiburg mono- and multisyllabic test as well as OLSA in quiet were measured in percent of correctly repeated material, while the OLSA in noise was measured as L50 SNR. The comparisons between T1 and T2 were calculated using paired T-tests; Cohen&#8217;s d was used to calculate the effect sizes. The NCIQ results and the Freiburg and OLSA measurements were checked for correlations using Pearson&#8217;s correlations. All calculations were performed using SPSS25 (IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp.).</Pgraph></TextBlock>
    <TextBlock linked="yes" name="Results">
      <MainHeadline>Results</MainHeadline><SubHeadline>Improvements in the NCIQ subscales, Freiburg speech test and OLSA</SubHeadline><Pgraph>In all subcategories of the NCIQ, as well as in the total score, there were significant improvements within the measured rehabilitation phase. Effect sizes were small to medium, according to the recommendations of Cohen <TextLink reference="8"></TextLink>. Patients who were measured in their first rehabilitation phase only showed significant increases in basic sound perception, self-esteem, activity limitation and social interaction. Only the patients in rehabilitation phase 2 or later also showed significant increases in advanced sound perception and speech production. There were also significant Improvements in the OLSA in noise and the Freiburg mono- and multisyllabic speech test, also with small to medium effect sizes <TextLink reference="8"></TextLink>. Only OLSA in quiet showed no significant increase (see Table 1 <ImgLink imgNo="1" imgType="table"/>).</Pgraph><SubHeadline>Correlations in NCIQ, OLSA and Freiburg speech test</SubHeadline><Pgraph>At T1, the result of the OLSA in quiet, as well as the OLSA in noise, showed a significant correlation with basic sound perception, advanced sound perception and speech production of the NCIQ as measured at T1. The same variables showed significant correlations with the OLSA in noise at T2. However, regarding the OLSA in quiet, at T2 all subscales of the NCIQ showed significantly positive correlations (see Table 2 <ImgLink imgNo="2" imgType="table"/>). </Pgraph><Pgraph>There were no significant correlations between the Freiburg mono- or multisyllabic speech tests and the NCIQ subscales, neither at T1, nor at T2.</Pgraph><SubHeadline>Initial measurement and gain</SubHeadline><Pgraph>In order to compare the initial measurements with the gain within a rehabilitation phase, the difference (delta) between T1 and T2 was calculated for each variable. The result was correlated with the measurement at T1. All correlations showed to be negative and significant at a p&#60;.05 level (see Table 3 <ImgLink imgNo="3" imgType="table"/>). Therefore, it could be shown that across all subcategories of the NCIQ, as well as in all audiological tests, the lower the initial value were, the higher the increases were within a rehabilitation phase.</Pgraph><SubHeadline>Gain in NCIQ, age and duration</SubHeadline><Pgraph>The deltas between T1 and T2 regarding the subscales of the NCIQ were also correlated with the duration of the rehabilitation phase, as well as the age of the patients. It was shown that the older patients showed a higher increase in basic sound perception (r&#61;.44; p&#61;.003), advanced sound perception (r&#61;.38; p&#61;.011) and self-esteem (r&#61;.347; p&#61;.021). Also, age correlated negatively with the duration of the rehabilitation phase (r&#61;&#8211;.300; p&#61;.026). However, the duration of the rehabilitation phase showed no significant relationship with the gain in the subscales of the NCIQ.</Pgraph></TextBlock>
    <TextBlock linked="yes" name="Conclusion">
      <MainHeadline>Conclusion</MainHeadline><Pgraph>Both the hearing measurement data and the NCIQ results show significant improvements within one rehabilitation phase. Significant increases in satisfaction with more complex listening tasks as well as increases in speech production only occur in later rehabilitation phases. However, all these are average values. In therapeutic contexts, it is always important to focus the individual, which may not show increases or even decreasing measures, especially in a subjective questionnaire which anchors on typical situations in everyday life. It is advisable to talk to the patient about such situations if the values, especially in the psychosocial subscales, deteriorate. </Pgraph><Pgraph>The correlations of the OLSA in quiet and in noise at T1 with the sound perception and speech production scales of the NCIQ suggest that the patients also subjectively rate their measured hearing ability as similarly high. At T2, the psychosocial subscales of the NCIQ also correlate with the result of the OLSA in quiet. It seems that, parallel to the objectively measured hearing gain in the course of the therapy, the patients also gain trust in their own ability to use their better hearing in everyday situations.</Pgraph><Pgraph>Patients with a poorer starting position seem to benefit the most across all tests. Longitudinal measures across the entire course of the therapy would be desirable to determine how the development continues and whether these are already signs of an early ceiling effect.</Pgraph><Pgraph>Older patients also showed more gains within a rehabilitation phase than younger patients, not only in sound perception, but also in their self-esteem, as measured by the NCIQ. This could point to a greater lack of possibilities for encouraging communicative situations in everyday life.</Pgraph></TextBlock>
    <TextBlock linked="yes" name="Notes">
      <MainHeadline>Notes</MainHeadline><SubHeadline>Conference presentation</SubHeadline><Pgraph>This contribution was presented at the 26<Superscript>th</Superscript> Annual Conference of the German Society of Audiology and published as an abstract <TextLink reference="9"></TextLink>.</Pgraph><SubHeadline>Competing interests</SubHeadline><Pgraph>The authors declare that they have no competing interests.</Pgraph></TextBlock>
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    <Media>
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          <Caption><Pgraph><Mark1>Table 1: Results of paired T-tests (start&#47;end of a rehabilitation phase) T2-T1</Mark1></Pgraph></Caption>
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          <Caption><Pgraph><Mark1>Table 2: Correlations OLSA (T1&#47;T2) and NCIQ (T1&#47;T2)</Mark1></Pgraph></Caption>
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          <Caption><Pgraph><Mark1>Table 3: Correlations measurement T1 with gain between T1 and T2</Mark1></Pgraph></Caption>
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