Oxalsäuredinitril
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of oxalonitrile [460‐19‐5].
There are no new data. The MAK value of 5 ml/m3 was determined in analogy to the more toxic metabolite hydrogen cyanide. The MAK value for hydrogen cyanide of 1.9 ml/m3 was derived from the human detoxification capacity per kg body weight with a respiratory volume of 10 m3. Therefore, the increased respiratory volume at the workplace has already been accounted for. The MAK value of oxalonitrile, which was set at 5 ml/m3 to reflect the 2.5‐fold higher acute toxicity of hydrogen cyanide, can be retained. This is also the case for Peak Limitation Category II and the excursion factor of 2 because no irritation was observed in humans below 16 ml/m3.
There are no developmental toxicity studies. Therefore, oxalonitrile is assigned to Pregnancy Risk Group D.
