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    5. The MAK Collection for Occupational Health and Safety
    6. Article
    7. Volume 4 (2019)
    8. Issue 3
    9. Addendum zu Chlorbenzol. Beurteilungswerte in biologischem Material
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Addendum zu Chlorbenzol

Beurteilungswerte in biologischem Material

Michael Nasterlack1
  Hans Drexler2 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig3 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission4

1 68526 Ladenburg, Deutschland
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
3 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
4 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated chlorobenzene after the MAK value for this substance had been lowered from 10 to 5 ml/m3. Therefore, the BAT value has to be re‐evaluated. Urinary excretion of 4‐chlorocatechol, the main metabolite of chlorobenzene, is considered to be the most appropriate biomarker after inhalation exposure. Available publications are described in detail. The regression equations derived from these studies agree well with each other. After an 8‐hour exposure to chlorobenzene a mean urinary excretion of 80 mg 4‐chlorocatechol per g creatinine can be expected. This value is set as BAT value. Sampling time is at the end of exposure or end of shift.

Keywords

chlorobenzene, 4-chlorocatechol, biological tolerance value, BAT value, developmental toxicity