Calciumbis(dinonylnaphthalinsulfonat)
MAK-Begründung
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated dinonylnaphthalene sulfonic acid, calcium salt [57855‐77‐3], to derive a maximum concentration at the workplace (MAK value), considering all toxicological endpoints. Available publications are described in detail. As the substance is irritating to rabbit eyes an irritating potential for the respiration tract of humans has to be assumed. Inhalation studies are lacking. Therefore, a MAK value could not be derived and the substance is assigned to Section II b of the List of MAK and BAT values. Data on the genotoxic potential is not available. The analogous barium salt is not genotoxic. Carcinogenicity studies and data on the potential of contact sensitization in humans are lacking. A Buehler test in guinea pigs has some limitations due to incomplete information on composition and purity of the test substance. Skin contact is not expected to contribute significantly to systemic toxicity.
