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    5. The MAK Collection for Occupational Health and Safety
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    7. Volume 3 (2018)
    8. Issue 2
    9. 2‐Methoxypropanol‐1
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



2‐Methoxypropanol‐1

MAK-Begründung, Nachtrag

  Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission2

1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for 2‐methoxypropanol‐1 [1589‐47‐5]. Available publications and unpublished study reports are described in detail.

Critical effects of 2‐methoxypropanol‐1 are its irritancy and teratogenicity. A MAK value of 5 ml/m3 had been set. By analogy with 2‐methoxypropylacetate‐1, this value is now reaffirmed.

Also, by analogy with 2‐methoxypropylacetate‐1 Peak Limitation Category I with excursion factor of 2 is set. 2‐Methoxypropanol‐1 ether remains assigned to Pregnancy Risk Group B and also remains designated with an “H” (for substances that can be absorbed through the skin in toxicologically relevant amounts).

Keywords

2-methoxypropanol-1, maximum workplace concentration, MAK value, peak limitation, irritation, teratogenicity, developmental toxicity, skin absorption