Di‐tert‐dodecyl pentasulfide / Di‐tert‐dodecyl polysulfide
MAK Value Documentation, addendum – Translation of the German version from 2018
Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value), the Pregnancy Risk Group and the absorption through the skin of di‐
The systemic toxicity is low and the substances are at most minimally irritating to skin and eye. Acidophilic globuli are present in the kidney of male rats in an oral 28‐day study at 50 mg/kg body weight and day, presumably resulting from an α2u‐globulin mediated kidney toxicity which, however, has not actually been proven. Based on this LOAEC the MAK value would be 10 mg/m3. However, the substances are poorly water‐soluble liquids and an accumulation in the lung is expected. Most of the di‐
New data on developmental toxicity are not available. As the MAK value is lowered, Pregnancy Risk Group C is retained. Skin contact is not expected to contribute significantly to systemic toxicity.
