N-Tosyl-6-aminocapronsäure

MAK-Begründung

  Andrea Hartwig¹ (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission<sup>2

1</sup> Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
² Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated N-tosyl-6-aminocaproic acid (6-[(4-methylphenyl)sulfonylamino]hexanoic acid) [78521-39-8] considering all toxicological end points. The substance is a complexing agent. As the influence of the complexing effect and the acid effect on the respiratory tract is not known and inhalation studies are not available, a maximum concentration at the workplace (MAK value) cannot be derived. The NOAEL for developmental effects in rats after oral administration was 100 mg/kg body weight and day. In a gavage study in rats that was carried out according to OECD Test Guideline 422, pup mortality was increased and pup body weights were decreased up to postnatal day 4 at 1600 mg/kg body weight and day. The substance is not genotoxic in bacteria or mammalian cells. Carcinogenicity studies are not available. There is no evidence of a contact sensitizing potential. Skin contact is not expected to contribute significantly to systemic toxicity.

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