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    3. Overview
    4. MAK Collection
    5. The MAK Collection for Occupational Health and Safety
    6. Article
    7. Volume 8 (2023)
    8. Issue 2
    9. Butylhydroxytoluol (BHT) – Ableitung eines BAR
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Butylhydroxytoluol (BHT) – Ableitung eines BAR

Beurteilungswerte in biologischem Material

Gabriele Leng1
  Hans Drexler2 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig3 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission4

1 Currenta GmbH & Co. OHG, CUR-SEL-SER-GS-BLM-Institut für Biomonitoring, 51368 Leverkusen, Deutschland
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
3 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
4 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

In 2012, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area derived a maximum workplace concentration (MAK value) for butylated hydroxytoluene (BHT) [128-37-0] of 10 mg/m3 (inhalable fraction). Measuring body burden after exposure to BHT showed BHT acid (3,5-di-tert-butyl-4-hydroxybenzoic acid) in urine to be an adequate biomarker. To date, no data have been published on urinary concentrations of BHT acid after occupational exposure to BHT with correlation to air concentrations of BHT or with effects from BHT exposure; as a result, no biological tolerance value (BAT value) can be derived. There are, however, data available for the derivation of a biological reference value (BAR). Based on the available data, a BAR of 7 µg BHT acid (after hydrolysis)/l urine has been established. Sampling time is at the end of exposure or the end of the shift.

Keywords

butylated hydroxytoluene (BHT), biological reference value, BAR