O,O,O-Triphenyl monothiophosphate

MAK Value Documentation – Translation of the German version from 2021

  Andrea Hartwig¹ (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
  MAK Commission<sup>2

1</sup> Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
² Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated O,O,O-triphenyl monothiophosphate [597-82-0] considering all toxicological end points. O,O,O-Triphenyl monothiophosphate is not neurotoxic in hens and rats and not irritating to the eyes and skin of rabbits. In an oral 13-week toxicity study with rats, increased liver weights and hepatocellular hypertrophy in addition to follicle cell hypertrophy and altered colloid in the thyroid gland were observed at 200 mg/kg body weight and day. On the basis of the NOAEL of 39.5 mg/kg body weight and day, a maximum concentration at the workplace (MAK value) of 20 mg/m³ has been established. As its critical effect is systemic, O,O,O-triphenyl monothiophosphate has been assigned to Peak Limitation Category II. The default excursion factor of 2 has been set because its half-life is not known. O,O,O-Triphenyl monothiophosphate was not found to be mutagenic in 2 tests with Salmonella and a mixture of triphenyl thiophosphate with butylated derivatives was not found to be clastogenic or mutagenic in vitro. In vivo genotoxicity tests and carcinogenicity studies have not been performed with O,O,O-triphenyl monothiophosphate. A screening study carried out according to OECD Test Guideline 421 to investigate the reproductive toxicity and toxicity of O,O,O-triphenyl monothiophosphate did not report any effects on perinatal reproduction; studies specifically investigating developmental toxicity are not available. The substance has therefore been assigned to Pregnancy Risk Group D. There are no studies which demonstrate that O,O,O-triphenyl monothiophosphate is sensitizing to the skin or airways. The substance does not penetrate the skin in toxicologically relevant amounts.

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