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    9. Addendum zu Benzol
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Addendum zu Benzol

Beurteilungswerte in biologischem Material

Thomas Kraus1
Michael Bader2
Katrin Klotz3
Wobbeke Weistenhöfer3
  Hans Drexler3 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig4 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission5

1 Institut für Arbeits‐ und Sozialmedizin, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Deutschland
2 BASF SE, Corporate Health Management, 67056 Ludwigshafen, Deutschland
3 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
4 Karlsruher Institut für Technologie (KIT), Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
5 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has derived biological reference values (BAR) and re‐evaluated the exposure equivalents for carcinogenic substances (EKA) for the urinary benzene metabolites S‐phenyl mercapturic acid, muconic acid and benzene in 2016. Available publications are described in detail.

The existing exposure equivalents for carcinogenic substances (EKA) for the benzene metabolites were re‐evaluated and extended especially to the low exposure range. For the parameter benzene in urine, new EKA were established.

Taking results of studies into consideration with persons of the general population occupationally not exposed to benzene, with sufficient number of cases and current biomonitoring methods, biological reference values (BAR) of 0.3 µg S‐phenyl mercapturic acid/g creatinine, 150 µg muconic acid/g creatinine and 0.3 µg benzene/l urine were established. Sampling time is at the end of exposure or the end of the working shift.

Keywords

benzene, S-phenylmercapturic acid, trans, trans-muconic acid, biological reference value, BAR, background exposure, exposure equivalents for carcinogenic substances, EKA