Distillates (petroleum), hydrotreated light
MAK Value Documentation, addendum – Translation of the German version from 2018
Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of hydrotreated light petroleum distillates [64742‐47‐8].
Critical effect of the vapour phase of hydrotreated light petroleum distillates is CNS depression in exposed subjects. A MAK value of 50 ml/m3 had been set taking into account the increased respiratory volume at the workplace as compared with volunteers at rest (see List of MAK and BAT Values, Sections I b and I c). For the aerosol phase the critical effect is considered to be the lung toxicity seen in rats and mice. A MAK value of 5 mg/m3 had been set as the respirable fraction (R). This value is now reaffirmed even considering the increased respiratory volume at the workplace.
Hydrotreated light petroleum distillates had been classified in Pregnancy Risk Group C because the NOAEC for developmental toxicity in rats is 400 ml/m3, the highest concentration tested. There is no new data on developmental toxicity. This classification is retained even considering the increased respiratory volume at the workplace.
