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    9. Fluorwasserstoff und anorganische Fluorverbindungen (Fluoride) – Addendum: Evaluierung einer Schwangerschaftsgruppe zum BAT-Wert
Cover: The MAK Collection for Occupational Health and Safety

The MAK Collection for Occupational Health and Safety

German Research Foundation – Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area
(MAK Commission)

ISSN 2509-2383



Fluorwasserstoff und anorganische Fluorverbindungen (Fluoride) – Addendum: Evaluierung einer Schwangerschaftsgruppe zum BAT-Wert

Beurteilungswerte in biologischem Material

Sandra Michaelsen1
Gerlinde Schriever-Schwemmer1 (Leitung der Arbeitsgruppe „Entwicklungstoxizität“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Hans Drexler2 (Leitung der Arbeitsgruppe „Beurteilungswerte in biologischem Material“ der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)
  MAK Commission3

1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut und Poliklinik für Arbeits-, Sozial- und Umweltmedizin, Henkestraße 9–11, 91054 Erlangen, Deutschland
3 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland

Abstract

In 2005, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated the maximum workplace concentration (MAK value) of hydrogen fluoride [7664-39-3] and fluorides [16984-48-8]. If the MAK values of 1 ml hydrogen fluoride/m3 (0.83 mg/m3) or 1 mg fluoride/m3, respectively, are not exceeded, prenatal toxic effects are not to be expected. Therefore, hydrogen fluoride and fluorides were classified in Pregnancy Risk Group C. In 2013, the biological tolerance value (BAT value) for hydrogen fluoride and inorganic fluorine compounds (fluorides) of 4 mg fluoride/l urine was established which protects against the long-term effects of fluoride such as skeletal fluorosis. The BAT value was not derived in correlation to the MAK value. For this reason, it is to be evaluated whether no prenatal toxic effects are to be expected when the BAT value is adhered to. By extrapolating the NOAEL (no observed adverse effect level) for developmental toxicity in rodent studies to fluoride concentrations in urine it could be concluded that Pregnancy Risk Group C is also valid for the BAT value.

Keywords

hydrogen fluoride and inorganic fluorine compounds (fluorides), biological tolerance value, BAT value, developmental toxicity, prenatal toxicity