1‐Ethoxy‐2‐propyl acetate
MAK Value Documentation, addendum – Translation of the German version from 2018
Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value), the Pregnancy Risk Group and absorption through the skin of 1‐ethoxy‐2‐propyl acetate [54839‐24‐6].
1‐Ethoxy‐2‐propyl acetate is weakly irritating to the skin and eyes of rabbits. The critical effect is CNS depression after repeated inhalative exposure with a NOAEC of 100 ml/m3 in a 28‐day study with rats. Based on this, the maximum concentration at the work place (MAK value) for 1‐ethoxy‐2‐propyl acetate is set at 20 ml/m3 (120 mg/m3). This value also protects against possible irritation, as local effects are not observed up to 1200 ml/m3 in the 28‐day rat inhalation study.
Since the critical effect of 1‐ethoxy‐2‐propyl acetate is systemic, Peak Limitation Category II is retained. There are still no specific toxicokinetic data available, so that the default excursion factor of 2 is also retained.
There are no data on reproduction toxicity with 1‐ethoxy‐2‐propyl acetate available. 1‐Ethoxy‐2‐propyl acetate remains assigned to Pregnancy Risk Group C in analogy to 1‐ethoxy‐2‐propanol. On the basis of data with 1‐ethoxy‐2‐propanol and other glycol ether acetates, skin contact is expected to contribute significantly to systemic toxicity and 1‐ethoxy‐2‐propyl acetate is designated with “H”.
