1,2‐Dihydro‐2,2,4‐trimethylchinolin, polymer
MAK-Begründung
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 1,2‐dihydro‐2,2,4‐trimethylquinoline, polymer [26780‐96‐1], an UVCB substance (“Unknown, of variable composition, or of biological origin”), considering all toxicological endpoints. Available publications and unpublished study reports are described in detail.
Critical effect is the liver toxicity observed in rats after 13‐week inhalative exposure resulting in a LOAEC of 15 mg/m3 and 2‐year oral exposure with a NOAEL of 3.1 mg/kg body weight and day. In studies with rabbits the polymer does not irritate the eyes or skin. No maximum concentration at the workplace (MAK value) can be derived, as the compositions of the polymers used in the studies are unknown.
1,2‐Dihydro‐2,2,4‐trimethylquinoline, polymer, is neither mutagenic in vitro nor carcinogenic. Genotoxicity studies in vivo are not available. 1,2‐Dihydro‐2,2,4‐trimethylquinoline, polymer, shows developmental toxicity in rats at an oral dose of 300 mg/kg body weight and day which is toxic to the dams.
Skin contact is not expected to contribute significantly to systemic toxicity. Limited data show no sensitization.
