1‐Ethoxy‐2‐propylacetat
MAK-Begründung, Nachtrag
Andrea Hartwig1 (Vorsitz der Ständigen Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institut für Angewandte Biowissenschaften, Abteilung Lebensmittelchemie und Toxikologie, Karlsruher Institut für Technologie (KIT), Adenauerring 20a, Geb. 50.41, 76131 Karlsruhe, Deutschland
2 Ständige Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Deutschland
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value), the Pregnancy Risk Group and absorption through the skin of 1‐ethoxy‐2‐propyl acetate [54839‐24‐6].
1‐Ethoxy‐2‐propyl acetate is weakly irritating to the skin and eyes of rabbits. The critical effect is CNS depression after repeated inhalative exposure with a NOAEC of 100 ml/m3 in a 28‐day study with rats. Based on this, the maximum concentration at the work place (MAK value) for 1‐ethoxy‐2‐propyl acetate is set at 20 ml/m3 (120 mg/m3). This value also protects against possible irritation, as local effects are not observed up to 1200 ml/m3 in the 28‐day rat inhalation study.
Since the critical effect of 1‐ethoxy‐2‐propyl acetate is systemic, Peak Limitation Category II is retained. There are still no specific toxicokinetic data available, so that the default excursion factor of 2 is also retained.
There are no data on reproduction toxicity with 1‐ethoxy‐2‐propyl acetate available. 1‐Ethoxy‐2‐propyl acetate remains assigned to Pregnancy Risk Group C in analogy to 1‐ethoxy‐2‐propanol. On the basis of data with 1‐ethoxy‐2‐propanol and other glycol ether acetates, skin contact is expected to contribute significantly to systemic toxicity and 1‐ethoxy‐2‐propyl acetate is designated with “H”.
