Crotonaldehyde
MAK Value Documentation, addendum – Translation of the German version from 2018
Andrea Hartwig1 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)MAK Commission2
1 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
2 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the germ cell mutagenicity and carcinogenicity of crotonaldehyde [4170‐30‐3, 123‐73‐9].
Crotonaldehyde is a highly reactive mutagenic and cytotoxic compound without metabolic activation.
An oral carcinogenicity study in male rats, with the liver as the only organ examined, provides at most only an indication of a carcinogenic potential. Crotonaldehyde remains assigned to Carcinogen Category 3B because of the still limited database.
Despite some methodical deficiencies, new in vivo studies with positive results for bone marrow and spermatocyte chromosomal aberrations as well as dominant lethal mutations in mice lead to a reclassification in Category 3A for Germ Cell Mutagens.
