2-Propanol – Addendum: evaluation of a pregnancy risk group for the BAT value
Assessment Values in Biological Material – Translation of the German version from 2023
Wobbeke Weistenhöfer1Sandra Michaelsen2
Gerlinde Schriever-Schwemmer2 (Head of the working group “Developmental Toxicity” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
Hans Drexler1 (Head of the working group “Assessment Values in Biological Material” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
Andrea Hartwig2 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
MAK Commission3
1 Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Henkestraße 9–11, 91054 Erlangen, Germany
2 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
3 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area re-evaluated and confirmed the maximum workplace concentration (MAK value) of 2-propanol [67-63-0]. If the MAK value of 200 ml 2‑propanol/m3 (500 mg/m3) is observed, no prenatal toxic effects are to be expected. Therefore, Pregnancy Risk Group C was likewise confirmed. In 2010, biological tolerance values (BAT values) of 25 mg acetone/l blood and 25 mg acetone/l urine were derived in correlation to the MAK value. Pregnancy Risk Group C is therefore similarly valid for the BAT value. In adherence with the BAT values of 25 mg acetone/l blood and 25 mg acetone/l urine, no prenatal toxic effects are to be expected.
