1,3-Dioxolane – Determination of 1,3-dioxolane in workplace air using gas chromatography (GC-FID)
Air Monitoring Method – Translation of the German version from 2022
Anna Laura Klimach1 (Method development)Ralph Hebisch1 (Chair of the working group “Air Analyses” of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
Thomas Helmut Brock2 (Head of the working group “Analytics”)
Ralf Schmitt3 (External verification)
Andrea Hartwig4 (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
MAK Commission5
1 Federal Institute for Occupational Safety and Health (BAuA), Friedrich-Henkel-Weg 1–25, 44149 Dortmund, Germany
2 German Social Accident Insurance, Institution for the raw materials and chemical industry, Prevention – Department of Hazardous Substances, Biological Agents and Analytical Chemistry, Kurfürsten-Anlage 62, 69115 Heidelberg, Germany
3 BASF SE, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany
4 Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
5 Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany
Abstract
This analytical method is a validated measurement procedure for the determination of 1,3-dioxolane [646-06-0] in workplace air in a concentration range of one tenth up to twice the currently valid Occupational Exposure Limit Value (OELV) in Germany of 150 mg/m3. For sampling, a defined volume of air is drawn through a sorbent tube (for thermal desorption) filled with Chromosorb 106. The flow rate is set to 5 ml/min and sampling is performed over 2 hours (which corresponds to a sampling volume of 600 ml). The samples to which cyclooctane is added as internal standard are thermally desorbed. The quantitative determination is based on a calibration function, whereby the 1,3-dioxolane concentration of the calibration standard is plotted against the intensities, calculated over the internal cyclooctane standard. The limit of quantification is 12.9 mg/m3based on an air sample volume of 600 ml. The mean recovery is 97% and the expanded uncertainty for the validation range of 16.3 to 293 mg/m3is 11.5 to 12.1%.
