2,4-Toluenediamine

MAK Value Documentation, supplement – Translation of the German version from 2021

  Andrea Hartwig¹ (Chair of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft)
  MAK Commission<sup>2

1</sup> Institute of Applied Biosciences, Department of Food Chemistry and Toxicology, Karlsruhe Institute of Technology (KIT), Adenauerring 20a, Building 50.41, 76131 Karlsruhe, Germany
² Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft, Kennedyallee 40, 53175 Bonn, Germany

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated data for the genotoxicity of 2,4-toluenediamine [95-80-7]. 2,4-Toluenediamine is clastogenic in vitro. In vivo, it is clastogenic in the liver, the target organ of carcinogenicity, but not in the bone marrow or germ cells. DNA adducts were induced in vitro and in vivo. 2,4-Toluenediamine demonstrates mutagenic potential in vitro and in vivo. The latter is evident only in the liver, but not in the kidneys. There are no data for the mutagenic potential of the substance in germ cells. Although the germ cells may be reached, no evidence of the active form was found in the germ cells. Therefore, 2,4-toluenediamine has been classified in Germ Cell Mutagenicity Category 3 B.

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